功能性三尖瓣关闭不全

继发于右心室扩大和/或三尖瓣环扩大及瓣叶系连的三尖瓣关闭不全,瓣叶无内在结构性改变。

定义

在解剖结构正常的三尖瓣叶存在收缩期系连及对合面积丧失的情况下,由于右心室扩大和功能不全和/或三尖瓣环扩大(继发于肺动脉高压、右心室压力/容量负荷过重或心房/心室心肌病)所致的三尖瓣反流 [V1] [V3] [G23-01] [G23-02]。

严重程度标准

  • 轻度(L):缩流颈(VC)< 3 mm;PISA半径 ≤ 5 mm(在奈奎斯特基线位移速度 28 cm/s 下);有效反流孔面积(EROA)< 0.20 cm²;反流容积(RV)< 30 mL/次;连续波多普勒:微弱或不完整射流;肝静脉收缩期前向血流保留 [V1] [V3] [G23-01] [G23-02]。
  • 中度(M):VC 3.0–6.9 mm;PISA半径 6–9 mm;EROA 0.20–0.39 cm²;RV 30–44 mL/次;连续波多普勒:致密抛物线状射流;肝静脉收缩期前向血流减弱平钝 [V1] [V3] [G23-01] [G23-02]。
  • 重度(G):VC ≥ 7.0 mm;PISA半径 > 9 mm;EROA ≥ 0.40 cm²;RV ≥ 45 mL/次;肝静脉出现收缩期血流逆转;连续波多普勒:因RV-RA压力迅速均等出现早期达峰的致密三角形全收缩期信号(v波截断征)[V1] [V3] [G23-01] [G23-02]。(临床提示:当代 5 级分类法还包括极重度伴VC ≥ 14 mm,EROA ≥ 0.60 cm²,以及特重度伴VC ≥ 21 mm,EROA ≥ 0.80 cm² [G23-01])。

分层表现

血流动力学

  • 重度病变中平均右心房压显著升高(G:10–18 mmHg),并与RV出现舒张期压力均等 [V1] [G23-01]。
  • 右心室容量负荷过重伴右心室舒张末期容积显著增加 [V1] [V3]。

心律

  • 心房颤动极常见,既是三尖瓣环和右心房扩大的病因也是其结果 [V1] [G23-01]。
  • 早期阶段为正常窦性心律 [V1]。

ECG

  • 右心房扩大(肺型P波,窦性心律下导联P波尖锐高大 > 2.5 mm)[E1]。
  • 右心室劳损或肥厚(右心室肥厚)及不完全性右束支传导阻滞 [E1] [E2]。

心音与杂音

  • 全收缩期反流性杂音:在胸骨左下缘第 4–5 肋间闻及的平台型收缩期杂音,吸气时强度典型增加(Rivero-Carvallo征)[B1] [G1-14]。
  • 右心第三心音(S3):严重容量负荷过重时在胸骨左下缘闻及的右心室快速充盈第三心音,吸气时增强 [G1-12]。
  • 第二心音(S2):若合并肺动脉高压则肺动脉瓣成分(P2)亢进 [G1-11] [C7]。

动脉脉搏

  • 外周动脉脉搏在低前向心输出量的晚期阶段正常或搏动容积减小(细脉)[B4]。

颈静脉搏动

  • 颈静脉怒张伴消除收缩期x降支的巨大“cv”波(巨大v波 / cv波),以及陡峭深邃的“y”降支(陡峭y降支)[B3]。

负荷试验

  • 深吸气(Rivero-Carvallo征):由于进入右心腔的静脉回流增加,显著增强三尖瓣收缩期杂音的声学强度 [B1]。
  • Valsalva动作(用力相):杂音强度减弱;用力解除后,三尖瓣杂音在最初 1–2 次心搏内立即恢复 [B1]。
  • 压迫肝脏(肝颈静脉回流征):增加静脉回流,增强杂音和cv波 [B1] [B3]。

模拟器严重程度分级

模拟器严重程度分级: 轻度, 中度, 重度
基线心律: 正常窦性心律

亦称为: 功能性三尖瓣关闭不全 · 继发性三尖瓣关闭不全 · 三尖瓣反流 · 功能性TR · TR

该组中的其他病变

文献来源

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  6. [E2] AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology . Circulation (2009) . DOI: 10.1161/CIRCULATIONAHA.108.191095 PubMed: 19228822
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  8. [G1-11] The Second Heart Sound . Clinical Methods: The History, Physical, and Laboratory Examinations (1990) . PubMed: 21250183
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